┘àϬϫÏÁÏÁ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î

 

┌®ÏºÏ▒Ï¿Ï▒Ï» Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î ┘ê Ï¿┘çÏ¿┘êÏ» ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ┘êÏ▒Ï▓Ï┤█î

 

Ï»Ï▒ Ï»┘å█îϺ█î Ϻ┘àÏ▒┘êÏ▓Ïî Ϻ┘ç┘à█îϬ ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î Ï¿█îÏ┤ ϺÏ▓ ┘¥█îÏ┤ ÏóÏ┤┌®ÏºÏ▒ Ï┤Ï»┘ç ϺÏ│Ϭ. Ϻ█î┘å Ï▒┘êÏ┤ ┌®┘ç Ï¿┘ç ┌®┘à┌® ┘ü┘åϺ┘êÏ▒█îÔÇî┘çϺ█î ┘¥Ï▓Ï┤┌®█î ϿϺÏ▓Ï│ϺϫϬ█î ┘¥█îÏ┤Ï▒┘üϬ┘ç ϺÏ▒ϺϪ┘ç ┘à█îÔÇîÏ┤┘êÏ»Ïî Ï¿┘ç ┘¥Ï▓Ï┤┌®Ïº┘å Ϻ█î┘å ┘üÏ▒ÏÁϬ Ï▒Ϻ ┘à█îÔÇîÏ»┘çÏ» ϬϺ ┘üÏ▒ϺϬÏ▒ ϺÏ▓ Ï»Ï▒┘àϺ┘åÔÇî┘çϺ█î Ï│┘åϬ█î Ï¡Ï▒┌®Ï¬ ┌®Ï▒Ï»┘ç ┘ê ┌®█î┘ü█îϬ ϿϺÏ▓Ϭ┘êϺ┘å█î Ï¿█î┘àϺÏ▒Ϻ┘å ┘êÏ▒Ï▓Ï┤┌®ÏºÏ▒ █îϺ ┘üÏ╣Ϻ┘ä Ï▒Ϻ ϺÏ▒Ϭ┘éϺ Ï»┘ç┘åÏ».

 

┬áϺ┘ç┘à█îϬ Ï│┘ä┘ê┘äÔÇî Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î

Ï│┘ä┘ê┘äÔÇî Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î Ï¿┘ç ┌®ÏºÏ▒Ï¿Ï▒Ï» ϬÏ▓Ï▒█î┘é █îϺ Ï¿┘ç ÔÇî┌®ÏºÏ▒┌»█îÏ▒█î Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î █îϺ ┘¥█îÏ┤ÔÇîÏ│ϺÏ▓ ┘àϺ┘å┘åÏ» ┬áMSC┘çϺ Ï»Ï▒ ϿϺ┘üϬÔÇî┘çϺ█î ÏóÏ│█îÏ¿ ÔÇîÏ»█îÏ»┘ç ┘åϺÏ┤█î ϺÏ▓ ┘êÏ▒Ï▓Ï┤ (┘àϺ┘å┘åÏ» ϬϺ┘åÏ»┘ê┘åÏî ┘ä█î┌»Ïº┘àϺ┘åÏî Ï║ÏÂÏ▒┘ê┘üÏî Ï╣ÏÂ┘ä┘ç) ┌»┘üϬ┘ç ┘à█îÔÇîÏ┤┘êÏ». ┘àÏÀϺ┘äÏ╣ϺϬ Ϻϫ█îÏ▒ ┘åÏ┤Ϻ┘å ┘à█îÔÇîÏ»┘ç┘åÏ» ┌®┘ç Ϻ█î┘å Ï▒┘ê█î┌®Ï▒Ï» ┘à█îÔÇîϬ┘êϺ┘åÏ» ϿϺ┘üϬÔÇî┘çϺ█î ÏóÏ│█îÏ¿ÔÇî Ï»█îÏ»┘ç Ï▒Ϻ ϬÏ▒Ï║█îÏ¿ Ï¿┘ç ϿϺÏ▓Ï│ϺÏ▓█î ┘å┘àϺ█îÏ» ┘ê ┘àÏ│█îÏ▒ Ï»Ï▒┘àϺ┘å█î ϼϻ█îÏ»█î ┘üÏ▒ϺϬÏ▒ ϺÏ▓ ÏÁÏ▒┘üϺ ┌®Ïº┘çÏ┤ Ï»Ï▒Ï» █îϺ ┘ü█îÏ▓█î┘êϬÏ▒Ϻ┘¥█î Ϻ█îϼϺϻ ┌®┘åÏ». Ï»Ï▒ Ï╣ÏÁÏ▒ Ϻ┘àÏ▒┘êÏ▓Ïî ┌å┘ç Ï»Ï▒ ┘êÏ▒Ï▓Ï┤ Ï¡Ï▒┘ü┘çÔÇîϺ█î ┘ê ┌å┘ç Ï║█îÏ▒Ï¡Ï▒┘ü┘çÔÇîϺ█îÏî ϿϺÏ▓┌»Ï┤Ϭ Ï│Ï▒█îÏ╣ ÔÇîϬÏ▒ Ï¿┘ç ┘üÏ╣Ϻ┘ä█îϬ ┘ê ┌®Ïº┘çÏ┤ Ï▒█îÏ│┌® Ï╣┘êÏ» ÏóÏ│█îÏ¿ ϺÏ▓ Ϻ┘ç┘à█îϬ ┘éϺϿ┘ä Ϭ┘êϼ┘ç█î Ï¿Ï▒Ï«┘êÏ▒ϻϺÏ▒ ϺÏ│Ϭ.

 

┘åÏ¡┘ê┘ç Ï╣┘à┘ä┌®Ï▒Ï» Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î

Ï»Ï▒ ┘üÏ▒Ïó█î┘åÏ» Ï│┘ä┘ê┘äÔÇî Ï»Ï▒┘àϺ┘å█îÏî Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î ┘ê ┘¥█îÏ┤ Ï│ϺÏ▓ ┘àϺ┘å┘åÏ» ┬áÏ│┘ä┘ê┘ä ┘çϺ█î ┘àÏ▓Ϻ┘åÏ┤█î┘à█î ϺÏ▓ ┘à┘åϺϿÏ╣█î ┘àϺ┘å┘åÏ» ┘àÏ║Ï▓ ϺÏ│Ϭϫ┘êϺ┘åÏî ┌åÏ▒Ï¿█î █îϺ ϿϺ┘üϬ Ï│█î┘å┘ê┘ê█îϺ┘ä ϺÏ│ϬϫÏ▒Ϻϼ ┘à█îÔÇîÏ┤┘ê┘åÏ». Ϻ█î┘å Ï│┘ä┘ê┘äÔÇî┘çϺ Ï│┘¥Ï│ Ï¿┘ç ┘àÏ¡┘ä ÏóÏ│█îÏ¿ ϬÏ▓Ï▒█î┘é ┘à█îÔÇî┌»Ï▒Ï»┘åÏ» █îϺ Ï¿Ï▒ ϿϺ┘üϬ ┘çÏ»┘ü ┘àϬ┘àÏ▒┌®Ï▓ ┘à█îÔÇîÏ┤┘ê┘åÏ». Ϻ█î┘å Ï▒┘êÏ┤ Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î ϿϺ ┌å┘åÏ» ┘à┌®Ïº┘å█îÏ│┘à ϺÏÁ┘ä█î Ï╣┘à┘ä ┘à█îÔÇî┌®┘åÏ»:

ϬϡÏ▒█î┌® ϿϺÏ▓Ï│ϺÏ▓█î ϿϺ┘üϬ ϺÏ▓ ÏÀÏ▒█î┘é Ϭ┘àϺ█îÏ▓ Ï│┘ä┘ê┘äÔÇî┘çϺ █îϺ ϬϡÏ▒█î┌® Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘ê┘à█î Ï¿┘ç ┘üÏ╣Ϻ┘ä Ï┤Ï»┘å.

┌®Ïº┘çÏ┤ Ϻ┘äϬ┘çϺϿ ┘ê Ϭ┘åÏ©█î┘à ┘¥ÏºÏ│Ï« Ϻ█î┘à┘å█î ┘à┘êÏÂÏ╣█îÏî ┌®┘ç ┘à█î ÔÇîϬ┘êϺ┘åÏ» Ï¿┘ç ϬÏ│Ï▒█îÏ╣ Ï¿┘çÏ¿┘êÏ» ┌®┘à┌® ┌®┘åÏ».

┘üÏ▒Ϻ┘ç┘à Ïó┘êÏ▒Ï»┘å ┘àÏ¡█îÏÀ█î ┘àÏ│ϺÏ╣Ï» Ï¿Ï▒Ϻ█î ϬÏ▒┘à█î┘à ϿϺ┘üϬ█î Ï¿┘çÔÇî ϼϺ█î ϬÏ┤┌®█î┘ä ϿϺ┘üϬ Ï▓Ï«┘à █îϺ ┘ü█îÏ¿Ï▒┘êÏ▓.

Ï¿┘ç Ϻ█î┘å ϬÏ▒Ϭ█îÏ¿Ïî Ϻ█î┘å Ï▒┘êÏ┤ ┘à█îÔÇîϬ┘êϺ┘åÏ» ┘à┌®┘à┘ä █îϺ ϼϺ█î┌»Ï▓█î┘å█î Ï¿Ï▒Ϻ█î Ï»Ï▒┘àϺ┘åÔÇî┘çϺ█î Ï│┘åϬ█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î ϿϺÏ┤Ï».

 

┘àÏ▓Ϻ█îϺ ┘åÏ│ϿϬ Ï¿┘ç Ï»Ï▒┘àϺ┘åÔÇî┘çϺ█î Ï│┘åϬ█î

• Ϻ█î┘å Ï▒┘êÏ┤ ┘åÏ│ϿϬ Ï¿┘ç ϬÏ▓Ï▒█î┘éϺϬ ϻϺÏ▒┘ê█î█î ┘ê Ï»Ï▒┘àϺ┘å ┘çϺ█î ┘éÏ»█î┘à█îÏî ϺÏ▓ ┘éϺϿ┘ä█îϬ ϬÏ▒┘à█î┘à ┘êϺ┘éÏ╣█î ϿϺ┘üϬ ϺÏ│Ϭ┘üϺϻ┘ç ┘à█î ┌®┘åÏ»Ïî ┘å┘ç ÏÁÏ▒┘üϺ┘ï ┌®Ïº┘çÏ┤ Ï╣┘äϺϪ┘à.
• ┘à█î Ϭ┘êϺ┘åÏ» Ï▓┘àϺ┘å ϿϺÏ▓┌»Ï┤Ϭ Ï¿┘ç ┘üÏ╣Ϻ┘ä█îϬ ┘êÏ▒Ï▓Ï┤█î Ï▒Ϻ ┌®┘êϬϺ┘çÔÇî ϬÏ▒ ┌®┘åÏ» ┘ê Ï▒█îÏ│┌® Ï╣┘êÏ» ÏóÏ│█îÏ¿ Ï▒Ϻ ┌®Ïº┘çÏ┤ Ï»┘çÏ».
• Ï»Ï▒ Ï¿Ï│█îϺÏ▒█î ϺÏ▓ ┘à┘êϺÏ▒Ï»Ïî Ϭϡ┘à┘ä Ï▒┘êÏ┤ Ï¿Ï▒Ϻ█î Ï¿█î┘àϺÏ▒Ϻ┘å Ï«┘êÏ¿ Ï¿┘êÏ»┘ç ┘ê Ï▒┘ê┘åÏ» ┘åÏ│ϿϬϺ┘ï ┌®┘à Ϭ┘çϺϼ┘à█î ϬÏ▒█î Ï»Ï▒ ┘à┘éϺ█îÏ│┘ç ϿϺ ϼÏ▒Ϻϡ█î ϿϺÏ▓ ϻϺÏ▒Ï».

 

 

┌®ÏºÏ▒Ï¿Ï▒Ï»┘çϺ█î Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î

ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ Ï│┘ä┘ê┘äÔÇî Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î Ï┤Ϻ┘à┘ä ┘à┘êϺÏ▒Ï» Ï▓█îÏ▒ ┘à█îÔÇîÏ┤┘êÏ»:

Ï»Ï▒┘àϺ┘å ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ┘ä█î┌»Ïº┘àϺ┘å█î ┘àϺ┘å┘åÏ» Anterior Cruciate Ligament (ACL) ┘ê Ï│Ϻ█îÏ▒ ┘¥ÏºÏ▒┌»█îÔÇî┘çϺ█î ┘ä█î┌»Ïº┘àϺ┘åÔÇî┘çϺ.

ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ϬϺ┘åÏ»┘ê┘å█î ┘ê Ϻ┘äϬ┘çϺϿ█î ┘àÏ▓┘à┘å ┘àϺ┘å┘åÏ» ϬϺ┘åÏ»┘ê┘å█îϬÏî ┘¥ÏºÏ▒┌»█î Ï▒┘êϬϺϬ┘êÏ▒┌®Ïº┘ü.

ÏóÏ│█îÏ¿ Ï║ÏÂÏ▒┘ê┘ü█î █îϺ ┘à┘üÏÁ┘ä█î ┘åϺÏ┤█î ϺÏ▓ ┘êÏ▒Ï▓Ï┤ █îϺ ┘üÏ▒Ï│Ϻ█îÏ┤Ïî ┌®┘ç Ï»Ï▒┘àϺ┘åÔÇî┘çϺ█î Ï│┘åϬ█î ┘àÏ¡Ï»┘êÏ» Ï¿┘êÏ»┘çÔÇîϺ┘åÏ».

ϿϺÏ▓Ϭ┘êϺ┘å█î ┘êÏ▒Ï▓Ï┤┌®ÏºÏ▒Ϻ┘å█î ┌®┘ç Ï¿┘çÔÇî Ï»┘åϿϺ┘ä ϿϺÏ▓┌»Ï┤Ϭ Ï│Ï▒█îÏ╣ ┘ê ┘¥Ïº█îϻϺÏ▒ Ï¿┘ç ┘üÏ╣Ϻ┘ä█îϬ ┘çÏ│Ϭ┘åÏ» ϿϺ ┌®Ïº┘çÏ┤ Ï▓┘àϺ┘å ϺÏ▓┌®ÏºÏ▒Ϻ┘üϬϺϻ┌»█î.

 

┌®Ï»Ïº┘à Ï¿█î┘àϺÏ▒Ϻ┘å ┘à█îÔÇîϬ┘êϺ┘å┘åÏ» ϺÏ▓ Ϻ█î┘å Ï▒┘êÏ┤ Ï¿┘çÏ▒┘ç Ï¿Ï¿Ï▒┘åϻσ

ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î ┘à█îÔÇîϬ┘êϺ┘åÏ» Ï¿Ï▒Ϻ█î ┌»Ï▒┘ê┘çÔÇî┘çϺ█î Ï▓█îÏ▒ Ϭ┘êÏÁ█î┘ç Ï┤┘êÏ»:

• ┘êÏ▒Ï▓Ï┤┌®ÏºÏ▒Ϻ┘å Ï¡Ï▒┘ü┘çÔÇîϺ█î █îϺ Ïó┘àϺϬ┘êÏ▒█î ┌®┘ç ÏóÏ│█îÏ¿ ϼϻ█î ϿϺ┘üϬ Ï¡Ï▒┌®Ï¬█î (┘ä█î┌»Ïº┘àϺ┘åÏî ϬϺ┘åÏ»┘ê┘åÏî Ï║ÏÂÏ▒┘ê┘ü) ϻϺÏ┤Ϭ┘çÔÇîϺ┘åÏ» ┘ê Ï¿┘ç Ï»┘åϿϺ┘ä ϿϺÏ▓┌»Ï┤Ϭ ┘àÏÀ┘àϪ┘å ┘çÏ│Ϭ┘åÏ».
• Ï¿█î┘àϺÏ▒Ϻ┘å ϿϺ ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ┘à┘üÏÁ┘ä█î █îϺ ϿϺ┘üϬ ┘åÏ▒┘à ┌®┘ç ϿϺ Ï»Ï▒┘àϺ┘åÔÇî┘çϺ█î Ï│┘åϬ█î ┘¥ÏºÏ│Ï« ┌®Ïº┘à┘ä ┘å┌»Ï▒┘üϬ┘çÔÇî Ϻ┘åÏ».
• Ï¿█î┘àϺÏ▒Ϻ┘å█î ┌®┘ç Ï╣┘äϺ┘é┘çÔÇî┘à┘åÏ» Ï¿┘ç ┌»Ï▓█î┘å┘çÔÇî┘çϺ█î ┌®┘àÔÇî Ϭ┘çϺϼ┘à█îÔÇîϬÏ▒ ┘åÏ│ϿϬ Ï¿┘ç ϼÏ▒Ϻϡ█î ┘çÏ│Ϭ┘åÏ» ┘ê Ϭ┘àϺ█î┘ä Ï¿┘ç Ï»Ï▒┘àϺ┘åÔÇî┘çϺ█î Ï▒┘êÏ▓ ϻϺÏ▒┘åÏ».
  
  

Ϻ┘äϿϬ┘ç ϬÏÁ┘à█î┘à ┘å┘çϺ█î█î ϿϺ█îÏ» Ϭ┘êÏ│ÏÀ ┘¥Ï▓Ï┤┌® ┘àϬϫÏÁÏÁ ┘ê ϿϺ Ï»Ï▒ ┘åÏ©Ï▒ ┌»Ï▒┘üϬ┘å ┘êÏÂÏ╣█îϬ ϿϺ┘ä█î┘å█îÏî Ϻ┘åϬϩϺÏ▒ϺϬ Ï¿█î┘àϺÏ▒Ïî ┘ê ┘à█îÏ▓Ϻ┘å Ï┤┘êϺ┘çÏ» Ï╣┘ä┘à█î ϺϬϫϺÏ░ Ï┤┘êÏ».

 

 

┘àÏ¡ÏÁ┘ê┘äϺϬ Ï┤Ï▒┌®Ï¬ ┘ê█îÏ▒ϺÏ│┘ä┘ê┘ä ϿϺ ϺÏ▒ϺϪ┘ç Ï»Ï▒┘àϺ┘å ┘çϺ█î ϺÏ│ϬϺ┘åϻϺÏ▒Ï» Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘êÏ▒Ï▓Ï┤█î ┘ê ┘ç┘à┌å┘å█î┘å Ï▒Ï╣Ϻ█îϬ ┘¥Ï▒┘êϬ┌®┘äÔÇî┘çϺ█î GMP ┘ê ┘üÏ▒Ϻ█î┘åÏ»┘çϺ█î ┌®┘åϬÏ▒┘ä ┌®█î┘ü█îϬÏî Ï¿┘ç ┌»┘ê┘å┘ç Ϻ█î ÏÀÏ▒Ϻϡ█î Ï┤Ï»┘çÔÇîϺ┘åÏ» ϬϺ ┘åϬϺ█îϼ ┘éϺϿ┘ä ϺϬ┌®Ïº ┘ê Ϭ┌®Ï▒ϺÏ▒┘¥Ï░█îÏ▒ ┘üÏ▒Ϻ┘ç┘à ┌®┘å┘åÏ». Ï»Ï▒ ÏÁ┘êÏ▒Ϭ█î ┌®┘ç ┘à█îÔÇîÏ«┘êϺ┘ç█îÏ» Ï»Ï▒┘àϺ┘åÔÇî┘çϺ█î ┘å┘ê█î┘å ┘ê ┘àÏ╣ϬϿÏ▒ Ï▒Ϻ Ï¿Ï▒Ϻ█î Ï¿█î┘àϺÏ▒Ϻ┘å Ï«┘êÏ» ┘üÏ▒Ϻ┘ç┘à ┌®┘å█îÏ»Ïî Ϭ█î┘à ┘àϺ Ïó┘àϺϻ┘çÔÇî█î ϺÏ▒ϺϪ┘ç ϼ┘äÏ│ϺϬ ┘ê ┘àÏ┤Ϻ┘êÏ▒┘ç ┘çϺ█î ϬϫÏÁÏÁ█î Ï¿┘ç ┘¥Ï▓Ï┤┌®Ïº┘å ┘ê ┘àϬϫÏÁÏÁϺ┘å Ϻ█î┘å Ï¡┘êÏ▓┘ç ϺÏ│Ϭ.

 

 

 

┘à┘éϺ┘äϺϬ ┘éϺϿ┘ä ϺÏ│Ϭ┘åϺϻ

https://pmc.ncbi.nlm.nih.gov/articles/PMC11603573/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8589434/

https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.908751/full