┘àϬϫÏÁÏÁ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î

Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î: Ï▒┘ê█î┌®Ï▒Ï»█î ┘å┘ê█î┘å ┘ê ϬϫÏÁÏÁ█î

Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î Ï¿┘ç Ï╣┘å┘êϺ┘å █î┌® Ï▒┘êÏ┤ Ï»Ï▒┘àϺ┘å█î ┘å┘ê█î┘åÏî ϿϺ Ϭ┘êϼ┘ç Ï¿┘ç Ϭ┘êϺ┘åϺ█î█îÔÇî┘çϺ█î Ï¿█î┘ê┘ä┘ê┌ÿ█î┌® ┘ê ϿϺÏ▓Ï│ϺÏ▓█îÔÇî┌®┘å┘åÏ»┘ç Ϻ┘å┘êϺÏ╣█î ϺÏ▓ Ï│┘ä┘ê┘ä ┘çϺ█î Ï¿Ï»┘åÏî Ϭ┘êϼ┘ç ┘ê█î┌ÿ┘çÔÇîϺ█î ┘à█îϺ┘å ┘àϬϫÏÁÏÁϺ┘å ┘¥Ï▓Ï┤┌®█î █îϺ┘üϬ┘ç ϺÏ│Ϭ. Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█îÏî Ï¿┘ç Ï╣┘å┘êϺ┘å █î┌®█î ϺÏ▓ Ï┤Ϻϫ┘çÔÇî┘çϺ█î Ï¿Ï▒ϼÏ│Ϭ┘ç ┘¥Ï▓Ï┤┌®█î ϿϺÏ▓Ï│ϺϫϬ█îÏî ┘å┘éÏ┤ ┘à┘ç┘à█î Ï»Ï▒ Ï¿┘çÏ¿┘êÏ» ┘ê ϿϺÏ▓┌»Ï▒ϻϺ┘åÏ»┘å Ï╣┘à┘ä┌®Ï▒Ï» Ϻ┘åϻϺ┘àÔÇî┘çϺ█î ÏóÏ│█îÏ¿ÔÇîÏ»█îÏ»┘ç Ï»Ï▒ Ï¡┘êÏ▓┘ç ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î Ϻ█î┘üϺ ┘à█îÔÇî┌®┘åÏ». Ϻ█î┘å Ï▒┘êÏ┤Ïî ϿϺ ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ Ϭ┘êϺ┘åϺ█î█îÔÇî┘çϺ█î Ï░ϺϬ█î Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î ┘ê ┘¥█îÏ┤ÔÇîÏ│ϺÏ▓ Ï»Ï▒ ϿϺÏ▓Ï│ϺÏ▓█î ϿϺ┘üϬÔÇî┘çϺÏî Ϻ┘à┌®Ïº┘å ϬÏ▒┘à█î┘à ┘à┘êϽÏ▒ ┘ê ┌®Ïº┘çÏ┤ Ï▓┘àϺ┘å Ï¿┘çÏ¿┘êÏ»█î Ï▒Ϻ ┘üÏ▒Ϻ┘ç┘à ┘à█îÔÇîÏó┘êÏ▒Ï».

ϺϽÏ▒Ï¿Ï«Ï┤█î Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ Ϻ┘äϬ█îϺ┘à ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ϺÏ│┌®┘äϬ█î-Ï╣ÏÂ┘äϺ┘å█î

┘àÏÀϺ┘äÏ╣ϺϬ ┘àϬÏ╣ϻϻ ┘åÏ┤Ϻ┘å ϻϺϻ┘çÔÇî Ϻ┘åÏ» ┌®┘ç Ϻ┘å┘êϺÏ╣ Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï»Ï▒┘àϺ┘å█î ┘åÏ©█îÏ▒ ┘¥┘äϺ┌®Ï¬ Ï║┘å█îÔÇîÏ┤Ï»┘ç ┬á(PRP)Ïî Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î ┘àÏ▓Ϻ┘åÏ┤█î┘à█î (MSCs) ┘ê ┘üÏ▒Ϻ┘êÏ▒Ï»┘çÔÇî┘çϺ█î ┘àÏ┤Ϭ┘é ϺÏ▓ ϿϺ┘üϬ ┌åÏ▒Ï¿█îÏî Ϭ┘êϺ┘åÏ│Ϭ┘ç ÔÇîϺ┘åÏ» ϺϽÏ▒Ï¿Ï«Ï┤█î ϿϺ┘äϺ█î█î Ï»Ï▒ Ï¿┘çÏ¿┘êÏ» Ϻ┘äϬ█îϺ┘à ϬϺ┘åÏ»┘ê┘åÔÇî┘çϺÏî ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ┘à┘üÏÁ┘ä█î ┘êÏ╣ÏÂ┘äϺ┘å█î ϻϺÏ┤Ϭ┘ç ϿϺÏ┤┘åÏ». PRPÏî Ï¿┘ç Ï»┘ä█î┘ä ϬÏ▒┌®█îϿϺϬ Ï║┘å█î ϺÏ▓ ┘üϺ┌®Ï¬┘êÏ▒┘çϺ█î Ï▒Ï┤Ï» ┘ê Ï│█î┌»┘åϺ┘äÔÇî┘çϺ█î ┘¥Ï▒┘êϬϪ█î┘å█îÏî Ï│Ï¿Ï¿ ┌®Ïº┘çÏ┤ Ϻ┘äϬ┘çϺϿ ┘ê ϬϡÏ▒█î┌® ϬÏ▒┘à█î┘à ϿϺ┘üϬ ┘åÏ▒┘à ┘à█îÔÇîÏ┤┘êÏ» ┌®┘ç Ï»Ï▒ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î ┌®ÏºÏ▒Ï¿Ï▒Ï» Ï¿Ï│█îϺÏ▒ ┘àÏñϽÏ▒█î ϻϺÏ▒Ï». ┘ç┘à┌å┘å█î┘åÏî MSC┘çϺ ϿϺ ┘ê█î┌ÿ┌»█îÔÇî┘çϺ█î ÏÂÏ» Ϻ┘äϬ┘çϺϿ█î ┘ê Ϭ┘êϺ┘åϺ█î█î Ϭ┘àϺ█îÏ▓ Ï¿┘ç Ï│┘ä┘ê┘äÔÇî┘çϺ█î ϿϺ┘üϬ ÏóÏ│█îÏ¿ÔÇîÏ»█îÏ»┘çÏî ┌»Ï▓█î┘å┘çÔÇî Ϻ█î Ϻ█îÏ»┘ç ÔÇîÏó┘ä Ï»Ï▒ Ï»Ï▒┘àϺ┘å Ï¿█î┘àϺÏ▒█îÔÇî┘çϺ█î ┘à┘üÏÁ┘ä█î ┘ê ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ┘àÏ▓┘à┘å Ï¿┘çÔÇî Ï┤┘àϺÏ▒ ┘à█îÔÇîÏó█î┘åÏ».

┘àÏ▓Ϻ█îϺ█î ϬϫÏÁÏÁ█î ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î

Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î┬áϿϺÏ╣Ͻ ϬÏ│Ï▒█îÏ╣ Ï▒┘ê┘åÏ» Ï¿┘çÏ¿┘êÏ»Ïî ┌®Ïº┘çÏ┤ Ï»Ï▒Ï»Ïî ┘ê ϺÏ▒Ϭ┘éϺÏí ┌®█î┘ü█îϬ Ï▓┘åÏ»┌»█î Ï¿█î┘àϺÏ▒Ϻ┘å ┘à█îÔÇîÏ┤┘êÏ». Ï¿Ï▒Ï«┘äϺ┘ü Ï»Ï▒┘àϺ┘åÔÇî┘çϺ█î Ï│┘åϬ█îÏî Ϻ█î┘å Ϭ┌®┘å█î┌® ϿϺ ϬϡÏ▒█î┌® ┘üÏ▒Ïó█î┘åÏ»┘çϺ█î ϿϺÏ▓Ï│ϺÏ▓█î ÏÀÏ¿█îÏ╣█î Ï¿Ï»┘åÏî ϺÏ▓ Ï¿Ï▒┘êÏ▓ Ï╣┘êϺÏ▒Ï ϼϺ┘åÏ¿█î ÏÀ┘ê┘äϺ┘å█î ÔÇî┘àϻϬ ϼ┘ä┘ê┌»█îÏ▒█î ┘à█îÔÇî┌®┘åÏ». ϿϺ Ϭ┘êϼ┘ç Ï¿┘ç ┘àÏÀϺ┘äÏ╣ϺϬ Ϻϫ█îÏ▒Ïî ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï¿┘ç ┘ê█î┌ÿ┘ç Ï»Ï▒ ┘à┘êϺÏ▒Ï» ÏóÏ▒ϬÏ▒┘êÏ▓ Ï▓Ϻ┘å┘êÏî ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ┘àÏ▓┘à┘å Ï╣ÏÂ┘ä┘ç ┘ê ϬϺ┘åÏ»┘ê┘åÏî ┘ê ϡϬ█î Ï┤Ï▒Ϻ█îÏÀ ϫϺÏÁ ┘å┘êÏ▒┘ê┘¥ÏºÏ¬█îÏî Ï│Ï¿Ï¿ Ï¿┘çÏ¿┘êÏ» ┘éϺϿ┘ä Ϭ┘êϼ┘ç Ï╣┘à┘ä┌®Ï▒Ï» Ï¿█î┘àϺÏ▒Ϻ┘å Ï┤Ï»┘ç ϺÏ│Ϭ.

Ï¿█î┘åÏ┤ÔÇî┘çϺ█î ┘å┘ê█î┘å Ï»Ï▒ Ϭϡ┘é█î┘éϺϬ ┘åÏ┤Ϻ┘å ┘à█îÔÇîÏ»┘çÏ» ┌®┘ç ϬÏ▒┌®█îÏ¿ Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î ϿϺ Ï▒┘êÏ┤ÔÇî┘çϺ█î Ϭ┘êϺ┘åÏ¿Ï«Ï┤█î ┘ü█îÏ▓█î┌®█î ┘à┘êϼϿ Ϻ┘üÏ▓Ϻ█îÏ┤ Ï¿┘éϺ█î Ï│┘ä┘ê┘äÔÇî┘çϺÏî Ϭ┘é┘ê█îϬ Ϭ┘àϺ█îÏ▓ Ï¿┘ç ϿϺ┘üϬÔÇî┘çϺ█î ┘çÏ»┘ü ┘ê ϺÏ▒Ϭ┘éϺ█î Ï¿┘çÏ¿┘êÏ»█î Ï╣┘à┘ä┌®Ï▒Ï»█î Ï¿█î┘àϺÏ▒Ϻ┘å ┘à█îÔÇîÏ┤┘êÏ». Ï¿Ï▒Ϻ█î ┘àϽϺ┘äÏî ┘àÏÀϺ┘äÏ╣ϺϬ ┘åÏ┤Ϻ┘å ϻϺϻ┘çÔÇîϺ┘åÏ» ┌®┘ç ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î Ï╣ÏÁÏ¿█î Ï»Ï▒ ÏóÏ│█îÏ¿ÔÇî┘çϺ█î ┘åϫϺÏ╣█î Ï¿┘ç ┘ç┘àÏ▒Ϻ┘ç Ϭ┘êϺ┘åÏ¿Ï«Ï┤█îÏî Ï╣┘à┘ä┌®Ï▒Ï» Ï¡Ï▒┌®Ï¬█î Ï▒Ϻ Ï¿┘ç ÏÀ┘êÏ▒ ┘àÏ╣┘å█îÔÇîϻϺÏ▒█î Ï¿┘çÏ¿┘êÏ» Ï¿Ï«Ï┤█îÏ»┘ç ϺÏ│Ϭ.

Ï╣┘äϺ┘ê┘ç Ï¿Ï▒ Ϻ█î┘åÏî Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ Ï»Ï▒┘àϺ┘å ÏóÏ│█îÏ¿ÔÇî┘çϺ█î Ï╣ÏÂ┘äϺ┘å█îÏî ϬϺ┘åÏ»┘ê┘å█î ┘ê Ï▒ϿϺÏÀ█î ϿϺ ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ Ï│┘ä┘ê┘äÔÇî┘çϺ█î ┘àÏ┤Ϭ┘é Ï┤Ï»┘ç ϺÏ▓ ┘àÏ║Ï▓ ϺÏ│Ϭϫ┘êϺ┘å ┘ê ┌åÏ▒Ï¿█î Ϭ┘êϺ┘åÏ│Ϭ┘ç ϺÏ│Ϭ Ï©Ï▒┘ü█îϬ ϿϺÏ▓Ï│ϺÏ▓█î Ï¿█î┘ê┘ä┘ê┌ÿ█î┌®█î ϿϺ┘üϬÔÇî┘çϺ█î ÏÂÏ╣█î┘ü Ï»Ï▒ ϿϺÏ▓Ϭ┘êϺ┘å█î Ï▒Ϻ Ϻ┘üÏ▓Ϻ█îÏ┤ Ï»┘çÏ». Ϻ█î┘å Ï▒┘êÏ┤ÔÇî┘çϺ Ï»Ï▒ ┌®┘åϺÏ▒ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î ┘à█îÔÇîϬ┘êϺ┘å┘åÏ» ┘à┘åϼÏ▒ Ï¿┘ç Ï¿┘çÏ¿┘êÏ» ┌®█î┘ü█îϬ Ï▓┘åÏ»┌»█î Ï¿█î┘àϺÏ▒Ϻ┘å Ï┤┘ê┘åÏ».

┌åÏ▒Ϻ ┘àÏ¡ÏÁ┘ê┘äϺϬ ┘ê█îÏ▒Ϻ Ï│┘ä┘ê┘ä Ï▒Ϻ Ϻ┘åϬϫϺϿ ┌®┘å█î┘àσ

┘ê█îÏ▒Ϻ Ï│┘ä┘ê┘ä ϿϺ Ï¿┘çÏ▒┘çÔÇî ┌»█îÏ▒█î ϺÏ▓ ϼϻ█îÏ» ϬÏ▒█î┘å Ϭ┌®┘å┘ê┘ä┘ê┌ÿ█îÔÇî┘çϺ ┘ê ┘üÏ▒┘à┘ê┘äϺÏ│█î┘ê┘åÔÇî┘çϺ█î ϺϫϬÏÁϺÏÁ█îÏî Ï«Ï»┘àϺϬ ┘¥█îÏ┤Ï▒┘üϬ┘ç ┘ê Ϻ█î┘à┘å┬áÏ│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î┬áÏ▒Ϻ ϺÏ▒ϺϪ┘ç ┘à█îÔÇîÏ»┘çÏ». ϬϫÏÁÏÁ ┘àϺ Ï¿Ï▒ ┘¥Ïº█î┘ç Ϭϡ┘é█î┘éϺϬ Ï╣┘ä┘à█î ┘ê ϬϼÏ▒Ï¿█îϺϬ ϿϺ┘ä█î┘å█î ┌»Ï│ϬÏ▒Ï»┘ç Ï¿┘åϺ Ï┤Ï»┘ç ϺÏ│Ϭ ┘ê Ϭ┘àϺ┘à█î ┘àÏ¡ÏÁ┘ê┘äϺϬ Ï»Ï▒ ÏóÏ▓┘àϺ█îÏ┤┌»Ïº┘çÔÇî┘çϺ█î ┘àÏ╣ϬϿÏ▒ ┘ê ϬϡϬ ϺÏ│ϬϺ┘åϻϺÏ▒Ï»┘çϺ█î Ï¿█î┘åÔÇîϺ┘ä┘à┘ä┘ä█î Ϭ┘ê┘ä█îÏ» ┘à█îÔÇîÏ┤┘ê┘åÏ». ϺÏÀ┘à█î┘åϺ┘å ϺÏ▓ ┌®█î┘ü█îϬ ϿϺ┘äϺ ┘ê ϺϽÏ▒Ï¿Ï«Ï┤█î ┘àÏ¡ÏÁ┘ê┘äϺϬÏî ϿϺÏ╣Ͻ Ï┤Ï»┘ç ┘ê█îÏ▒Ϻ Ï│┘ä┘ê┘ä Ï¿┘ç Ï╣┘å┘êϺ┘å █î┌® Ï┤Ï▒█î┌® ┘éϺϿ┘ä ϺÏ╣Ϭ┘àϺϻ Ï¿Ï▒Ϻ█î ┘¥Ï▓Ï┤┌®Ïº┘å ┘ê ┘àÏ▒Ϻ┌®Ï▓ Ï»Ï▒┘àϺ┘å█î Ï┤┘åϺϫϬ┘ç Ï┤┘êÏ».

Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î┬áϿϺ ϺϽϿϺϬ ϿϺ┘ä█î┘å█îÏî █î┌®█î ϺÏ▓ Ï¿┘çϬÏ▒█î┘å Ï▒Ϻ┘ç┌®ÏºÏ▒┘çϺ█î Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ϺÏ▒Ϭ┘éϺÏí Ï│┘äϺ┘àϬ Ï¿█î┘àϺÏ▒Ϻ┘å ϺÏ│Ϭ ┘ê ┘àϺ ┘à┘üϬϫÏ▒█î┘à ┌®┘ç Ϻ█î┘å ┘ü┘åϺ┘êÏ▒█î ┘¥█îÏ┤Ï▒┘üϬ┘ç Ï▒Ϻ Ï»Ï▒ Ï»Ï│ϬÏ▒Ï│ ┘àϬϫÏÁÏÁ█î┘å ┘éÏ▒ϺÏ▒ Ï»┘ç█î┘à.

┘à┘åϺϿÏ╣ ┘éϺϿ┘ä ϺÏ│Ϭ┘åϺϻ

https://www.nature.com/articles/s41536-021-00191-7#Abs1

https://pmc.ncbi.nlm.nih.gov/articles/PMC5488706

https://pmc.ncbi.nlm.nih.gov/articles/PMC6942086

https://pmc.ncbi.nlm.nih.gov/articles/PMC8645794

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