Ï»Ï▒┘àϺ┘å Ï»Ï▒Ï» ┘àÏ▓┘à┘åÏî Ï¿┘çÔÇî┘ê█î┌ÿ┘ç Ï»Ï▒ Ï¿█î┘àϺÏ▒Ϻ┘å ┘à┘éϺ┘ê┘à Ï¿┘ç ϻϺÏ▒┘ê ┘ê Ï▒┘êÏ┤ÔÇî┘çϺ█î ┌®┘äϺÏ│█î┌®Ïî ┘ç┘à┌å┘åϺ┘å █î┌®█î ϺÏ▓ ┌åϺ┘äÏ┤ÔÇî┘çϺ█î ϺÏÁ┘ä█î ┘¥Ï▓Ï┤┌®█î ┘àÏ»Ï▒┘å ϺÏ│Ϭ. Ï»Ï▒ Ϻ█î┘å ┘à█îϺ┘åÏî Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ Ï»Ï▒Ï» Ï¿┘çÔÇîÏ╣┘å┘êϺ┘å Ï▒┘ê█î┌®Ï▒Ï»█î ┘å┘ê█î┘å ┘ê Ï╣┘ä┘à█î ϺÏ▓ Ï¡┘êÏ▓┘ç ┘¥Ï▓Ï┤┌®█î ϿϺÏ▓Ï│ϺϫϬ█îÏî Ϭ┘êϺ┘åÏ│Ϭ┘ç ┘å┌»Ïº┘ç Ï¿Ï│█îϺÏ▒█î ϺÏ▓ ┘¥┌ÿ┘ê┘çÏ┤┌»Ï▒Ϻ┘å ┘ê ┘¥Ï▓Ï┤┌®Ïº┘å Ï»Ï▒Ï» Ï▒Ϻ Ï¿┘ç Ï«┘êÏ» ϼ┘äÏ¿ ┌®┘åÏ». Ϻ█î┘å ┘ü┘åϺ┘êÏ▒█î ┘å┘ç ÔÇîϬ┘å┘çϺ Ï¿Ï▒ ┌®┘åϬÏ▒┘ä Ï╣┘äϺϪ┘àÏî Ï¿┘ä┌®┘ç Ï¿Ï▒ ϬÏ▒┘à█î┘à Ï╣┘äϬÔÇî┘çϺ█î Ï▓█îÏ│Ϭ█î Ï»Ï▒Ï» ┘àϬ┘àÏ▒┌®Ï▓ ϺÏ│Ϭ. Ï▒┘ê█î┌®Ï▒Ï»█î ┌®┘ç Ï┤Ï▒┌®Ï¬ ┘ê█îÏ▒Ϻ Ï│┘ä┘ê┘ä ϿϺ Ϭ┌®█î┘ç Ï¿Ï▒ ┘ü┘åϺ┘êÏ▒█îÔÇî┘çϺ█î Ï│┘ä┘ê┘ä█î ┘ê Ï▓█îÏ▒Ï│ϺϫϬÔÇî┘çϺ█î Ϭ┘ê┘ä█îÏ» GMP Ïó┘å Ï▒Ϻ Ï¿┘ç ┘àÏ▒Ï¡┘ä┘ç ϿϺ┘ä█î┘å█î Ï▒Ï│Ϻ┘åÏ»┘ç ϺÏ│Ϭ.
Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î ┘àÏ▓Ϻ┘åÏ┤█î┘à█î (MSCs) ┘¥Ï▒┌®ÏºÏ▒Ï¿Ï▒Ï» ϬÏ▒█î┘å Ï│┘ä┘ê┘äÔÇî┘çϺ Ï»Ï▒ Ϻ█î┘å Ï¡┘êÏ▓┘ç ┘çÏ│Ϭ┘åÏ». Ϻ█î┘å Ï│┘ä┘ê┘äÔÇî┘çϺ ϿϺ ϻϺÏ┤Ϭ┘å Ϭ┘êϺ┘åϺ█î█î Ï«┘êÏ» Ϭϼϻ█îÏ»█îÏî Ϭ┘àϺ█îÏ▓ Ï¿┘ç ϿϺ┘üϬÔÇî┘çϺ█î ┘àϫϬ┘ä┘üÏî ┘ê ϬÏ▒Ï┤Ï¡ ┘üϺ┌®Ï¬┘êÏ▒┘çϺ█î ÏÂϻϺ┘äϬ┘çϺϿÏî ┘å┘éÏ┤ ┌®┘ä█îÏ»█î Ï»Ï▒ ϿϺÏ▓Ï│ϺÏ▓█î ϿϺ┘üϬÔÇî┘çϺ█î ÏóÏ│█îÏ¿ÔÇîÏ»█îÏ»┘ç ϻϺÏ▒┘åÏ». ┘àÏÀϺ┘äÏ╣ϺϬ ┘åÏ┤Ϻ┘å ┘à█îÔÇîÏ»┘çÏ» ┌®┘ç ϺϽÏ▒ϺϬ Ï»Ï▒┘àϺ┘å█î Ïó┘åÔÇî┘çϺ Ï¿█îÏ┤ϬÏ▒ ϺÏ▓ ÏÀÏ▒█î┘é ÏóÏ▓ϺϻÏ│ϺÏ▓█î Ï▒█îÏ▓┘à┘ê┘ä┌®┘ê┘äÔÇî┘çϺÏî Ϻ┌»Ï▓┘êÏ▓┘ê┘àÔÇî ┘çϺ ┘ê ┘üϺ┌®Ï¬┘êÏ▒┘çϺ█î Ï▒Ï┤Ï» ϺÏ╣┘àϺ┘ä ┘à█îÔÇîÏ┤┘êÏ» ϬϺ ϼϺ█î┌»Ï▓█î┘å█î ┘àÏ│Ϭ┘é█î┘à Ï│┘ä┘ê┘ä█î.
Ï»Ï▒ Ï»Ï▒Ï»┘çϺ█î ┘å┘êÏ▒┘ê┘¥ÏºÏ¬█î┌® ┘ê Ϻ┘äϬ┘çϺϿ█îÏî Ϻ█î┘å Ï│┘ä┘ê┘äÔÇî┘çϺ ϿϺ ϬÏ╣Ï»█î┘ä ┘¥ÏºÏ│Ï« Ϻ█î┘à┘å█îÏî ┌®Ïº┘çÏ┤ ┘à█î┌®Ï▒┘êϺ┘äϬ┘çϺϿ Ï╣ÏÁÏ¿█îÏî ┘ê ϬϡÏ▒█î┌® Ï▒┌»Ï▓Ϻ█î█î (angiogenesis)Ïî ┘à█îÔÇîϬ┘êϺ┘å┘åÏ» ┘üÏ▒Ïó█î┘åÏ» ϿϺÏ▓Ï│ϺÏ▓█î Ï╣ÏÁÏ¿█î Ï▒Ϻ ϬÏ│┘ç█î┘ä ┌®Ï▒Ï»┘ç ┘ê Ï┤ϻϬ Ï»Ï▒Ï» Ï▒Ϻ Ï¿┘çÔÇîÏÁ┘êÏ▒Ϭ ┘¥Ïº█îϻϺÏ▒ ┌®Ïº┘çÏ┤ Ï»┘ç┘åÏ». Ϻ█î┘å ┘ê█î┌ÿ┌»█îÔÇî┘çϺ ϿϺÏ╣Ͻ Ï┤Ï»┘ç ┌®┘ç Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ Ï»Ï▒Ï» Ï¿┘çÔÇîÏ╣┘å┘êϺ┘å ┌»Ï▓█î┘å┘ç ÔÇîϺ█î Ϻ█î┘à┘åÏî ┘éϺϿ┘ä Ϭ┌®Ï▒ϺÏ▒ ┘ê Ï¿┘ä┘åÏ»┘àϻϬ Ï»Ï▒ ┘àÏ»█îÏ▒█îϬ Ï»Ï▒Ï»┘çϺ█î ┘àÏ▓┘à┘å ┘à┘êÏ▒Ï» Ϭ┘êϼ┘ç ┘éÏ▒ϺÏ▒ ┌»█îÏ▒Ï».
Ï»Ï▒ ┌®ÏºÏ▒ÏóÏ▓┘àϺ█î█îÔÇî ┘çϺ█î ϿϺ┘ä█î┘å█î ┘à┘åϬÏ┤Ï▒Ï┤Ï»┘ç Ï»Ï▒ ┘àϼ┘äϺϬ Ï╣┘ä┘à█î ┘àÏ╣ϬϿÏ▒Ïî ϺÏ▓ ϼ┘à┘ä┘ç Pain Physician ┬á┘ê Frontiers in Cell and Developmental BiologyÏî ϬÏ▓Ï▒█î┘é Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î ┘àÏ▓Ϻ┘åÏ┤█î┘à█î Ï»Ï▒ Ï¿█î┘àϺÏ▒Ϻ┘å ┘àϿϬ┘äϺ Ï¿┘ç ÏóÏ▒ϬÏ▒┘êÏ▓Ïî Ï»█îÏ│┌®┘ê┘¥ÏºÏ¬█î ┌®┘àÏ▒█î ┘ê Ï»Ï▒Ï»┘çϺ█î ┘å┘êÏ▒┘ê┘¥ÏºÏ¬█î┌®Ïî ┘à┘êϼϿ ┌®Ïº┘çÏ┤ ┘à█îϺ┘å┌»█î┘å █│█░ ϬϺ █Â█░ Ï»Ï▒ÏÁÏ»█î Ï»Ï▒ Ï┤ϻϬ Ï»Ï▒Ï» ϬϺ █▒█▓ ┘àϺ┘ç ┘¥Ï│ ϺÏ▓ Ï»Ï▒┘àϺ┘å Ï┤Ï»┘ç ϺÏ│Ϭ.
Ϻ█î┘å █îϺ┘üϬ┘çÔÇî┘çϺ ┘åÏ┤Ϻ┘å ┘à█îÔÇîÏ»┘çÏ» ┌®┘ç Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î ┘å┘çÔÇî Ϭ┘å┘çϺ Ï»Ï▒ ┌®┘åϬÏ▒┘ä Ï»Ï▒Ï» ┘àÏñϽÏ▒ ϺÏ│ϬÏî Ï¿┘ä┌®┘ç Ï»Ï▒ ϬÏ▒┘à█î┘à Ï│ϺϫϬϺÏ▒█î ┘à┘üÏÁ┘äÏî Ï»█îÏ│┌® ┘ê ϿϺ┘üϬ Ï╣ÏÁÏ¿█î ┘å█îÏ▓ ┘å┘éÏ┤ ϻϺÏ▒Ï».
Ï┤Ï▒┌®Ï¬ ┘ê█îÏ▒ϺÏ│┘ä┘ê┘ä ϿϺ Ï¿┘çÏ▒┘ç ÔÇî┌»█îÏ▒█î ϺÏ▓ ┘ü┘åϺ┘êÏ▒█îÔÇî┘çϺ█î Ϻ┘åÏ¡ÏÁϺÏ▒█î Ï»Ï▒ ┌®Ï┤Ϭ ┘ê Ϭ┘àϺ█îÏ▓ Ï│┘ä┘ê┘ä█î ϬϡϬ Ï┤Ï▒Ϻ█îÏÀ ┬áGMPÏî ┌®┘åϬÏ▒┘ä ┌®█î┘ü█î Ï»┘é█î┘é ┘ê ┘üÏ▒┘à┘ê┘äϺÏ│█î┘ê┘åÔÇî ┘çϺ█î ϺϫϬÏÁϺÏÁ█îÏî Ï▒Ϻ┘ç┌®ÏºÏ▒┘çϺ█î█î Ϻ█î┘à┘å ┘ê Ï╣┘ä┘à█î Ï¿Ï▒Ϻ█î Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ Ï»Ï▒Ï» ϺÏ▒ϺϪ┘ç ┘à█îÔÇîÏ»┘çÏ».
┘àÏ¡ÏÁ┘ê┘äϺϬ Ï┤Ï▒┌®Ï¬ ┘ê█îÏ▒ϺÏ│┘ä┘ê┘ä Ï┤Ϻ┘à┘ä ┌®█îϬ ┘çϺ█î ϺÏ│ϬϺ┘åϻϺÏ▒Ï» ┘¥Ï▓Ï┤┌®█î ϿϺÏ▓Ï│ϺϫϬ█î; ┌®█îϬ SVFÏî ┌®█îϬ PRPÏî ┌®█îϬ PRF ┘ê ┌®█îϬ ϼϻϺÏ│ϺÏ▓█î Ï│┘ä┘ê┘ä Ï¿┘å█îϺϻ█î ┘àÏ▓Ϻ┘åÏ┤█î┘à ϺÏ▓ ϿϺ┘üϬ ┌åÏ▒Ï¿█î Ï«┘êÏ» ┘üÏ▒Ï» ┘çÏ│Ϭ.
┬áϺÏ▓ Ï┤┘àϺ ┘¥Ï▓Ï┤┌®Ïº┘å ┘ê ┘àϬϫÏÁÏÁϺ┘å ┌»Ï▒Ϻ┘à█î Ï»Ï╣┘êϬ ┘à█î ┌®┘å█î┘à ϼ┘çϬ ┘ç┘à┌®ÏºÏ▒█î ┘ê Ï»Ï▒█îϺ┘üϬ ┘àÏ┤Ϻ┘êÏ▒┘ç Ï▒Ϻ█î┌»Ïº┘å ϿϺ ┘àϺ Ï»Ï▒ ϺÏ▒ϬϿϺÏÀ ϿϺÏ┤█îÏ».
https://pubmed.ncbi.nlm.nih.gov/28535552
