Ï│┘ä┘ê┘äÔÇî Ï»Ï▒┘àϺ┘å█î Ï»Ï▒ ┘¥Ï▓Ï┤┌®█î ϬÏ▒┘à█î┘à█îÏî ϺÏ▒Ϭ┘ê┘¥Ï»█îÏî Ï│Ï▒ÏÀϺ┘å ┘ê ┘åϺϿϺÏ▒┘êÏ▒█î

Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬áÏ»Ï▒ ┘¥Ï▓Ï┤┌®█î ϬÏ▒┘à█î┘à█î ┘ê ϿϺÏ▓Ï│ϺϫϬ█î

Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î Ϻ┘àÏ▒┘êÏ▓┘ç Ï¿┘ç █î┌®█î ϺÏ▓ ϺÏ▒┌®Ïº┘å ϺÏÁ┘ä█î ÏÀÏ¿ ϿϺÏ▓Ï│ϺϫϬ█î ϬϿϻ█î┘ä Ï┤Ï»┘ç ┘ê Ï»Ï▒ Ï¡┘êÏ▓┘çÔÇî┘çϺ█î ϺÏ▒Ϭ┘ê┘¥Ï»█îÏî Ϻ┘å┌®┘ê┘ä┘ê┌ÿ█îÏî ϺÏ▒┘ê┘ä┘ê┌ÿ█îÏî Ï»Ï▒┘àϺϬ┘ê┘ä┘ê┌ÿ█îÏî ┘àÏ»█îÏ▒█îϬ Ï»Ï▒Ï» ┘ê Ï¿█î┘àϺÏ▒█îÔÇî┘çϺ█î Ï▓┘åϺ ┘å ┘ê Ï▓Ϻ█î┘àϺ┘å ϼϺ█î┌»Ïº┘ç█î ┘ê█î┌ÿ┘ç █îϺ┘üϬ┘ç ϺÏ│Ϭ .Ï»Ï▒ Ϻ█î┘å Ï▒┘ê█î┌®Ï▒Ï» ϺÏ▓ Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï▓┘åÏ»┘çÏî Ï¿┘çÔÇî ┘ê█î┌ÿ┘ç ┬áÏ│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î ┘àÏ▓Ϻ┘åÏ┤█î┘à█î (MSCs) ┘àÏ┤Ϭ┘é ϺÏ▓ ┘àÏ║Ï▓ ϺÏ│Ϭϫ┘êϺ┘åÏî ϿϺ┘üϬ ┌åÏ▒Ï¿█î ┘ê ϼ┘å█î┘å█î Ï¿Ï▒Ϻ█î ϬÏ╣Ï»█î┘ä Ϻ┘äϬ┘çϺϿÏî ϬÏ▒┘à█î┘à ┘àϺϬÏ▒█î┌®Ï│ ϫϺÏ▒ϼÔÇî Ï│┘ä┘ê┘ä█î ┬á┘ê Ï¡┘àϺ█îϬ ϺÏ▓ ϿϺÏ▓Ï│ϺÏ▓█î Ï╣┘à┘ä┌®Ï▒Ï» ϿϺ┘üϬ ÏóÏ│█îÏ¿ÔÇîÏ»█îÏ»┘ç ϺÏ│Ϭ┘üϺϻ┘ç ┘à█îÔÇîÏ┤┘êÏ».

Ï»Ï▒┘àϺ┘å Ï¿█î┘àϺÏ▒█î ┘çϺ█î ϺÏ▒Ϭ┘ê┘¥Ï»█î ┘ê Ï»Ï▒Ï»┘çϺ█î ┘àÏ▓┘à┘å ϿϺ Ï│┘ä┘ê┘ä Ï»Ï▒┘àϺ┘å█î

Ï¿Ï▒ ϺÏ│ϺÏ│ ┘à┘éϺ┘ä┘ç ┘ê ┘àÏ▒┘êÏ▒┘çϺ█î ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ ┘àϼ┘ä┘ç Stem Cell Research & Therapy Ïî ϬÏ▓Ï▒█î┘é ϻϺϫ┘ä ÔÇî┘à┘üÏÁ┘ä█î ┬áÏ│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î ┘àÏ▓Ϻ┘åÏ┤█î┘à█î Ï»Ï▒ ϺÏ│ϬϪ┘êÏóÏ▒ϬÏ▒█îϬ (ÏóÏ▒ϬÏ▒┘êÏ▓) Ï▓Ϻ┘å┘ê ┘à█îÔÇîϬ┘êϺ┘åÏ» ϿϺ ┌®Ïº┘çÏ┤ Ϻ┘äϬ┘çϺϿ Ï│█î┘å┘ê┘ê█îϺ┘äÏî ┘à┘çϺÏ▒ Ï│█îϬ┘ê┌®Ïº█î┘åÔÇî┘çϺ█î Ϻ┘äϬ┘çϺϿ█î ┘ê ϬϡÏ▒█î┌® Ï│┘åϬÏ▓ ┘àϺϬÏ▒█î┌®Ï│ Ï║ÏÂÏ▒┘ê┘ü█îÏî ┘à┘åϼÏ▒ Ï¿┘ç ┌®Ïº┘çÏ┤ Ï»Ï▒Ï» ┘ê Ï¿┘çÏ¿┘êÏ» Ï╣┘à┘ä┌®Ï▒Ï» ┘à┘üÏÁ┘ä Ï┤┘êÏ» (1). Ï»Ï▒ ┌®ÏºÏ▒ÏóÏ▓┘àϺ█î█îÔÇî┘çϺ█î ┘üϺÏ▓ I/II ┘ê II/III ┌®┘ç Ï»Ï▒ ┌ÿ┘êÏ▒┘åϺ┘äÔÇî┘çϺ█î ϬÏ▒ϺÏ▓ ϿϺ┘äϺ█î ÏÀÏ¿ ϿϺÏ▓Ï│ϺϫϬ█î ┘àϺ┘å┘åÏ» Regenerative Therapy ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘çÔÇîϺ┘åÏ»Ïî ┌»Ï▓ϺÏ▒Ï┤ Ï┤Ï»┘ç ϺÏ│Ϭ ┌®┘ç Ϻ█î┘å ϬÏ▓Ï▒█î┘éÔÇî┘çϺ ϿϺÏ╣Ͻ ┌®Ïº┘çÏ┤ ┘à█îÏ▓Ϻ┘å Ï»Ï▒Ï»Ïî Ï¿┘çÏ¿┘êÏ» Ï┤ϺϫÏÁ Ï╣┘à┘ä┌®Ï▒Ï»█î ┘ê Ï»Ï▒ Ï¿Ï▒Ï«█î ┘àÏÀϺ┘äÏ╣ϺϬÏî Ï¿┘çÏ¿┘êÏ» Ï┤ϺϫÏÁÔÇî┘çϺ█î ϬÏÁ┘ê█îÏ▒Ï¿Ï▒ϻϺÏ▒█î MRI ┘ê ┌®┘åÏ» Ï┤Ï»┘å Ï▒┘ê┘åÏ» ϬϫÏ▒█îÏ¿ Ï║ÏÂÏ▒┘ê┘ü Ï┤Ï»┘çÔÇîϺ┘åÏ».

Ï»Ï▒ ┌®┘åϺÏ▒ MSC┘çϺÏî ┘àÏ¡ÏÁ┘ê┘äϺϬ ┘àϿϬ┘å█î Ï¿Ï▒ ϿϺ┘üϬ ┌åÏ▒Ï¿█î ┘àϺ┘å┘åÏ» ┘üÏ▒Ϻ┌®Ï┤┘å Ï╣Ï▒┘ê┘é█îÔÇôϺÏ│ϬÏ▒┘ê┘àϺ█î█î (SVF) ┘ê ┘ç┘à┌å┘å█î┘å PRP ┘ê PRF Ï¿┘çÔÇîÏ╣┘å┘êϺ┘å ┘¥┘äϬ┘üÏ▒┘àÔÇî┘çϺ█î ┘à┌®┘à┘ä Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬á┌®┘äϺÏ│█î┌® Ï»Ï▒ ϺÏ▒Ϭ┘ê┘¥Ï»█î ┘àÏÀÏ▒Ï¡ ┘çÏ│Ϭ┘åÏ». Ϻ█î┘å ϬÏ▒┌®█îϿϺϬ ϿϺ Ϻ█îϼϺϻ ┘àÏ¡█îÏÀ█î Ï║┘å█î ϺÏ▓ ┘üϺ┌®Ï¬┘êÏ▒┘çϺ█î Ï▒Ï┤Ï» ┘ê Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¡┘àϺ█îϬ█îÏî ┘à█îÔÇîϬ┘êϺ┘å┘åÏ» Ï¿┘éϺ█î Ï│┘ä┘ê┘äÔÇî┘çϺ█î ϬÏ▓Ï▒█î┘éÔÇîÏ┤Ï»┘ç ┘ê ϿϺÏ▓Ï│ϺÏ▓█î ϿϺ┘üϬ█î Ï▒Ϻ Ϭ┘é┘ê█îϬ ┌®┘å┘åÏ» ┘ê Ï¿Ï▒Ϻ█î Ï¿█î┘àϺÏ▒Ϻ┘å█î ┌®┘ç Ï»Ï▒ ┘àÏ▒Ϻϡ┘ä ┘àϬ┘êÏ│ÏÀ ÏóÏ▒ϬÏ▒┘êÏ▓ ┘éÏ▒ϺÏ▒ ϻϺÏ▒┘åÏ» ┘ê ┘àϺ█î┘ä Ï¿┘ç ϬÏ╣┘ê█î┘é ϼÏ▒Ϻϡ█î ϬÏ╣┘ê█îÏ ┘à┘üÏÁ┘ä ┘çÏ│Ϭ┘åÏ»Ïî ┌»Ï▓█î┘å┘çÔÇîϺ█î ┌®ÏºÏ▒Ïó┘àÏ» Ï¿┘ç ÔÇîÏ┤┘àϺÏ▒ ┘à█îÔÇîÏ▒┘ê┘åÏ».

Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î Ï»Ï▒ Ï│Ï▒ÏÀϺ┘å ┘ê GVHD

Ï»Ï▒ Ï¡┘êÏ▓┘ç Ϻ┘å┌®┘ê┘ä┘ê┌ÿ█îÏî Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î Ï╣┘àϻϬϺ┘ï Ï»Ï▒ ┘éϺ┘äÏ¿ Ϻ█î┘à┘å┘êϬÏ▒Ϻ┘¥█îÔÇî┘çϺ█î Ï│┘ä┘ê┘ä█î ┘¥█îÏ┤Ï▒┘üϬ┘ç ┘àϺ┘å┘åÏ» CARÔÇæT cell therapy ┘ê ┬áTumorÔÇæinfiltrating lymphocytes (TILs) ┬áÏ┤┘åϺϫϬ┘ç ┘à█îÔÇîÏ┤┘êÏ». Ï¿┘ç ┌»┘üϬ┘ç ┘à┘éϺ┘ä┘ç ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ ┘àϼ┘ä┘ç Signal Transduction and Targeted TherapyÏî Ï»Ï▒┘àϺ┘å ϿϺ Ï│┘ä┘ê┘äÔÇî┘çϺ█î CARÔÇæT Ï»Ï▒ Ͽϻϫ█î┘à█îÔÇî┘çϺ█î Ï«┘ê┘å█îÏî Ï¿┘çÔÇî ┘ê█î┌ÿ┘ç ┬á┘ä┘êÏ│┘à█îÔÇî┘çϺ ┘ê ┘ä┘å┘ü┘ê┘àÔÇî┘çϺÏî ┘åϬϺ█îϼ ┌åÏ┤┘à┌»█îÏ▒█î ϺÏ▓ ┘åÏ©Ï▒ ┘åÏ▒Ï« ┘¥ÏºÏ│Ï« Ï╣┘à█î┘é ┘ê ┘¥Ïº█îϻϺÏ▒ ϻϺÏ┤Ϭ┘ç ┘ê Ï»Ï▒ ┌å┘åÏ»█î┘å Ϻ┘åÏ»█î┌®ÏºÏ│█î┘ê┘å Ï¿┘ç ϬÏú█î█îÏ» Ï▒Ï│█îÏ»┘ç ϺÏ│Ϭ. Ï¿┘ç ┘å┘é┘ä ϺÏ▓ ┘à┘éϺ┘ä┘ç ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ The Lancet OncologyÏî Ï»Ï▒┘àϺ┘å ┘àϿϬ┘å█î Ï¿Ï▒ TIL Ï»Ï▒ ┘à┘äϺ┘å┘ê┘à ┘àϬϺÏ│ϬϺϬ█î┌® Ï¿┘çÔÇîÏ╣┘å┘êϺ┘å █î┌® ┌»Ï▓█î┘å┘ç ┘àÏñϽÏ▒ ϿϺ ┘åÏ▒Ï« ┘¥ÏºÏ│Ï« ┘¥Ïº█îϻϺÏ▒ ┘éϺϿ┘äÔÇî Ϭ┘êϼ┘ç ┘àÏÀÏ▒Ï¡ Ï┤Ï»┘ç ┘ê Ϻ┌®┘å┘ê┘å Ï»Ï▒ ϡϺ┘ä ϬÏ╣┘à█î┘à Ï¿┘ç Ï│Ϻ█îÏ▒ Ϭ┘ê┘à┘êÏ▒┘çϺ ϺÏ│Ϭ.

Ï»Ï▒ ┌®┘åϺÏ▒ Ï»Ï▒┘àϺ┘å ┘àÏ│Ϭ┘é█î┘à Ï│Ï▒ÏÀϺ┘åÏî Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î Ï»Ï▒ ┘àÏ»█îÏ▒█îϬ Ï¿Ï▒Ï«█î ϺÏ▓ Ï╣┘êϺÏ▒Ï ┘åϺÏ┤█î ϺÏ▓ Ï»Ï▒┘àϺ┘å┘çϺ█î Ï│Ï▒ÏÀϺ┘å ┌®ÏºÏ▒Ï¿Ï▒Ï» ┘ê█î┌ÿ┘çÔÇîϺ█î ϻϺÏ▒Ï». Ï¿Ï╣┘å┘êϺ┘å ┘àϽϺ┘äÏî Ï»Ï▒┘àϺ┘å ϿϺ MSC Ï»Ï▒ ┘¥█îÏ┤┌»█îÏ▒█î ┘ê Ï»Ï▒┘àϺ┘å Ï¿█î┘àϺÏ▒█î ┘¥█î┘ê┘åÏ» Ï╣┘ä█î┘ç ┘à█îÏ▓ϿϺ┘å ┬á(GVHD) ┌®┘ç █î┌®█î ϺÏ▓ Ï╣┘êϺÏ▒Ï ϼϻ█î ┘¥Ï│ ϺÏ▓ ┘¥█î┘ê┘åÏ» Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î Ï«┘ê┘åÔÇîÏ│ϺÏ▓ ϺÏ│ϬÏî Ϻ┘ç┘à█îϬ ϻϺÏ▒Ï». Ï¿Ï▒ ϺÏ│ϺÏ│ ┘à┘éϺ┘ä┘ç ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ Frontiers in ImmunologyÏî Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î/ϺÏ│ϬÏ▒┘ê┘àϺ█î█î ┘àÏ▓Ϻ┘åÏ┤█î┘à█î Ï¿┘ç Ï»┘ä█î┘ä Ï«┘êϺÏÁ Ϻ█î┘à┘ê┘å┘ê┘àÏ»┘ê┘äϺϬ┘êÏ▒█î Ï«┘êÏ»Ïî Ï»Ï▒ ┘¥█îÏ┤┌»█îÏ▒█î ┘ê Ï»Ï▒┘àϺ┘å GVHD ϡϺϻ ┘ê ┘àÏ▓┘à┘å ┘à┘êÏ▒Ï» Ï¿Ï▒Ï▒Ï│█î ┘ê ϺÏ│Ϭ┘üϺϻ┘ç ┘éÏ▒ϺÏ▒ ┌»Ï▒┘üϬ┘çÔÇîϺ┘åÏ».┘àϬϺÏó┘åϺ┘ä█îÏ▓ ┌®ÏºÏ▒ÏóÏ▓┘àϺ█î█îÔÇî┘çϺ█î ϬÏÁϺϻ┘ü█î Ï┤Ï»┘ç ┘åÏ┤Ϻ┘å ┘à█îÔÇîÏ»┘çÏ» ┌®┘ç ϺÏ│Ϭ┘üϺϻ┘ç ┘¥█îÏ┤┌»█îÏ▒Ϻ┘å┘ç ϺÏ▓ MSC┘çϺ Ï»Ï▒ ┘¥█î┘ê┘åÏ» Ïó┘ä┘ê┌ÿ┘å█î┌® ┘à█îÔÇîϬ┘êϺ┘åÏ» Ï┤█î┘êÏ╣ GVHD ┬áϡϺϻ ┘ê ┘àÏ▓┘à┘å Ï▒Ϻ ┌®Ïº┘çÏ┤ Ï»┘çÏ»Ïî Ï¿Ï»┘ê┘å Ïó┘å┌®┘ç Ï¿┘çÔÇîÏÀ┘êÏ▒ ┘àÏ╣┘å█îÔÇîϻϺÏ▒ Ï«ÏÀÏ▒ Ï╣┘êÏ» Ͽϻϫ█î┘à█î Ï▒Ϻ Ϻ┘üÏ▓Ϻ█îÏ┤ Ï»┘çÏ».

Ï»Ï▒ GVHD ϡϺϻ ┘à┘éϺ┘ê┘à Ï¿┘ç ϺÏ│ϬÏ▒┘êϪ█îÏ»Ïî ┘àÏÀϺ┘äÏ╣┘ç ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ ┘àϼ┘ä┘ç Lancet ┘åÏ┤Ϻ┘å ϻϺϻ┘ç ϺÏ│Ϭ ┌®┘ç ϬÏ▓Ï▒█î┘é ┘êÏ▒█îÏ»█î MSC┘çϺ█î Ïó┘ä┘ê┌ÿ┘å Ï»Ï▒ Ï¿█î┘àϺÏ▒Ϻ┘å ϿϺ Ï»Ï▒┌»█îÏ▒█î Ï┤Ï»█îÏ» ┌®Ï¿Ï» ┘ê Ï»Ï│Ϭ┌»Ïº┘ç ┌»┘êϺÏ▒Ï┤ ┘à█îÔÇîϬ┘êϺ┘åÏ» ϿϺ ┘¥ÏºÏ│Ï« ϿϺ┘ä█î┘å█î ┘à┘åϺÏ│Ï¿ ┘ê Ï¿┘çÏ¿┘êÏ» Ï¿┘éϺ█î Ï▓█îÏ▒┌»Ï▒┘ê┘çÔÇî┘çϺ█î ┘¥Ï▒Ï«ÏÀÏ▒ ┘ç┘àÏ▒Ϻ┘ç ϿϺÏ┤Ï».┘åϬϺ█îϼ ϼϻ█îÏ» Ï»Ï▒ϿϺÏ▒┘ç Ï│┘ä┘ê┘äÔÇî┘çϺ█î ϺÏ│ϬÏ▒┘ê┘àϺ█î█î ┘àÏ┤Ϭ┘é ϺÏ▓ ϼ┘üϬ ┘åÏ┤Ϻ┘å ┘à█îÔÇîÏ»┘çÏ» ┌®┘ç Ϻ█î┘å Ï│┘ä┘ê┘äÔÇî┘çϺ ϿϺ ϺϽÏ▒ϺϬ Ϻ█î┘à┘ê┘å┘ê┘àÏ»┘ê┘äϺϬ┘êÏ▒█î ┘é┘ê█î Ï«┘êÏ» ϬϺϽ█îÏ▒ Ï▓█îϺϻ█î Ï»Ï▒ ┘àÏ»█îÏ▒█îϬ GVHD ϡϺϻ ϻϺÏ▒┘åÏ».Ï»Ï▒ ┘àϼ┘à┘êÏ╣Ïî ┘à┘ü┘ç┘ê┘à Ϻ┘å┌®┘ê┘ä┘ê┌ÿ█î ┘àÏ»Ï▒┘å ┘ê ┘àÏ»█îÏ▒█îϬ GVHD ┘¥█î┘ê┘åÏ»█î ┘åϺ┌»Ï│Ï│Ϭ┘å█î ϿϺ Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┘ê Ϻ█î┘à┘ê┘å┘êϬÏ▒Ϻ┘¥█î Ï¿Ï▒┘éÏ▒ϺÏ▒ ┌®Ï▒Ï»┘ç ϺÏ│Ϭ.

Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬áÏ»Ï▒ Ï¿█î┘àϺÏ▒█îÔÇî┘çϺ█î ϺÏ▒┘ê┘ä┘ê┌ÿ█î

ϺÏ▒┘ê┘ä┘ê┌ÿ█î ϺÏ▓ Ï¡┘êÏ▓┘çÔÇî┘çϺ█î█î ϺÏ│Ϭ ┌®┘ç ϻϺϻ┘çÔÇî┘çϺ█î Ϻ┘ê┘ä█î┘ç Ϻ┘åÏ│Ϻ┘å█î Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î Ï»Ï▒ Ïó┘å Ï¿Ï▒Ϻ█î Ï»Ï▒┘àϺ┘å ϺϫϬ┘äϺ┘äϺϬ ┘åÏ╣┘êÏ© ┘ê Ï¿█îÔÇîϺϫϬ█îϺÏ▒█î ϺϻÏ▒ϺÏ▒█î Ï»Ï▒ Ï»Ï│ϬÏ▒Ï│ ϺÏ│Ϭ. Ï¿Ï▒ ϺÏ│ϺÏ│ ┘à┘éϺ┘ä┘ç ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ World Journal of UrologyÏî Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬áϿϺ ┬áMSC┘çϺ█î ┘àÏ┤Ϭ┘é ϺÏ▓ ┘àÏ║Ï▓ ϺÏ│Ϭϫ┘êϺ┘å ┘ê ϿϺ┘üϬ ┌åÏ▒Ï¿█î Ï»Ï▒ ┘àÏ»┘äÔÇî┘çϺ█î ┘¥█îÏ┤ÔÇîϿϺ┘ä█î┘å█î ϺϫϬ┘äϺ┘ä ┘åÏ╣┘êÏ©Ïî ϿϺ Ï¿┘çÏ¿┘êÏ» ┘åϪ┘ê┘êϺÏ│┌®┘ê┘äϺÏ▒█îÏ▓ϺÏ│█î┘ê┘åÏî ┌®Ïº┘çÏ┤ ┘ü█îÏ¿Ï▒┘êÏ▓ ϼÏ│┘à ┌®Ïº┘êÏ▒┘å┘êÏ│ ┘ê Ϻ┘üÏ▓Ϻ█îÏ┤ Ϭ┘ê┘ä█îÏ» Ϻ┌®Ï│█îÏ» ┘å█îϬÏ▒█î┌® ┘ç┘àÏ▒Ϻ┘ç Ï¿┘êÏ»┘ç ┘ê ┘àÏÀϺ┘äÏ╣ϺϬ Ϻ┘ê┘ä█î┘ç Ϻ┘åÏ│Ϻ┘å█î ┘å█îÏ▓ Ï¿┘çÏ¿┘êÏ» Ï┤ϺϫÏÁÔÇî┘çϺ█î Ï╣┘à┘ä┌®Ï▒Ï» ┘åÏ╣┘êÏ© Ï▒Ϻ ┘åÏ┤Ϻ┘å ϻϺϻ┘çÔÇîϺ┘åÏ».

┘àÏÀϺ┘äÏ╣ϺϬ ┘üϺÏ▓ I/II ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ ┘àϼ┘ä┘ç Stem Cells Translational Medicine Ï▒┘ê█î Ï¿█î┘àϺÏ▒Ϻ┘å ┘àϿϬ┘äϺ Ï¿┘ç Ï¿█îÔÇîϺϫϬ█îϺÏ▒█î ϺϻÏ▒ϺÏ▒█î ┘¥Ï│ ϺÏ▓ ┘¥Ï▒┘êÏ│ϬϺϬ┌®Ï¬┘ê┘à█î ┘ê Ï¿█îÔÇîϺϫϬ█îϺÏ▒█î ϺÏ│ϬÏ▒Ï│█îÏî ┘åÏ┤Ϻ┘å ϻϺϻ┘çÔÇîϺ┘åÏ» ┌®┘ç ϬÏ▓Ï▒█î┘é ϻϺϫ┘äÔÇîϺÏ│┘ü┘å┌®Ï¬Ï▒█î MSC┘çϺ█î ϺϬ┘ê┘ä┘ê┌» ┘àÏ┤Ϭ┘é ϺÏ▓ ┌åÏ▒Ï¿█î ┌®Ïº┘à┘äϺ Ϻ█î┘à┘å Ï¿┘êÏ»┘ç ┘ê Ï»Ï▒ Ï¿Ï«Ï┤ ┘éϺϿ┘ä ÔÇîϬ┘êϼ┘ç█î ϺÏ▓ Ï¿█î┘àϺÏ▒Ϻ┘å ϿϺÏ╣Ͻ ┌®Ïº┘çÏ┤ ϡϼ┘à ┘åÏ┤Ϭ ϺϻÏ▒ϺÏ▒Ïî ┌®Ïº┘çÏ┤ ϬÏ╣ϻϺϻ ┘¥Ï» ┘àÏÁÏ▒┘ü█î ┘ê Ï¿┘çÏ¿┘êÏ» ┌®█î┘ü█îϬ Ï▓┘åÏ»┌»█î ┘à█îÔÇîÏ┤┘êÏ».

Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬áÏ»Ï▒ Ï¡┘êÏ▓┘ç Ï»Ï▒┘àϺϬ┘ê┘ä┘ê┌ÿ█î

Ï»Ï▒┘àϺϬ┘ê┘ä┘ê┌ÿ█î ϿϺÏ▓Ï│ϺϫϬ█î ϺÏ▓ Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬á┘ê ┘àÏ¡ÏÁ┘ê┘äϺϬ ┘àÏ┤Ϭ┘é ϺÏ▓ Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î Ï¿Ï▒Ϻ█î Ï»Ï▒┘àϺ┘å Ï▓Ï«┘àÔÇî┘çϺ█î ┘àÏ▓┘à┘åÏî Ï│┘êϫϬ┌»█îÔÇî┘çϺÏî ϺÏ│┌®ÏºÏ▒┘çϺ ┘ê ϼ┘êϺ┘åÔÇîÏ│ϺÏ▓█î ┘¥┘êÏ│Ϭ█î Ï¿┘çÏ▒┘ç ┘à█îÔÇî┌»█îÏ▒Ï». Ï¿Ï▒ ϺÏ│ϺÏ│ ┘àÏ▒┘êÏ▒┘çϺ█î ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ ┌ÿ┘êÏ▒┘åϺ┘äÔÇî┘çϺ█î Ï¡┘êÏ▓┘ç ϿϺÏ▓Ï│ϺϫϬ█îÏî MSC┘çϺ ┘ê Ï│┘ä┘ê┘äÔÇî┘çϺ█î ┘àÏ┤Ϭ┘é ϺÏ▓ ϿϺ┘üϬ ┌åÏ▒Ï¿█î ϿϺ ϬÏ▒Ï┤Ï¡ ┘üϺ┌®Ï¬┘êÏ▒┘çϺ█î█î ┘àϺ┘å┘åÏ» ┬áVEGFÏî HGF ┬á┘ê TGFÔÇæ╬▓ Ïî ϿϺÏ╣Ͻ Ϭ┘é┘ê█îϬ Ïó┘å┌ÿ█î┘ê┌ÿ┘åÏ▓Ïî ┌®Ïº┘çÏ┤ Ϻ┘äϬ┘çϺϿ ┘àÏ▓┘à┘å ┘ê ϬÏ│┘ç█î┘ä ┘à┘çϺϼÏ▒Ϭ ┌®Ï▒ϺϬ█î┘å┘êÏ│█îϬÔÇî┘çϺ ┘ê ┘ü█îÏ¿Ï▒┘êÏ¿┘äϺÏ│ϬÔÇî┘çϺ ┘à█îÔÇîÏ┤┘ê┘åÏ»Ïø Ϻ█î┘å ┘üÏ▒Ïó█î┘åÏ»┘çϺ Ï¿Ï▒Ϻ█î ϬÏ▒┘à█î┘à Ï▓Ï«┘àÔÇî┘çϺ█î IschemicÏî Ï»█îϺϿϬ█î ┘ê Ï│┘êϫϬ┌»█î Ï¡█îϺϬ█î ┘çÏ│Ϭ┘åÏ».

┘àÏÀϺ┘äÏ╣ϺϬ ϿϺ┘ä█î┘å█î Ϻ┘ê┘ä█î┘ç ┘åÏ┤Ϻ┘å ϻϺϻ┘çÔÇîϺ┘åÏ» ┌®┘ç ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ MSC┘çϺ █îϺ ┘àÏ¡ÏÁ┘ê┘äϺϬ ┌åÏ▒Ï¿█î Ï»Ï▒ ┌®┘åϺÏ▒ ┘àÏ▒Ϻ┘éϿϬ ϺÏ│ϬϺ┘åϻϺÏ▒Ï» Ï▓Ï«┘àÏî ┘à█îÔÇîϬ┘êϺ┘åÏ» Ï▓┘àϺ┘å ϿϺÏ▓Ï│ϺÏ▓█î ┘äϺ█î┘ç Ϻ┘¥█îϬ┘ä█îϺ┘ä Ï▒Ϻ ┌®Ïº┘çÏ┤ Ï»┘çÏ» ┘ê ┌®█î┘ü█îϬ ┘å┘çϺ█î█î ϺÏ│┌®ÏºÏ▒ Ï▒Ϻ ϺÏ▓ ┘åÏ©Ï▒ ┌®Ï┤Ï│Ϻ┘å█îÏî Ï▒┘å┌» ┘ê ϩϺ┘çÏ▒ Ï¿┘çÏ¿┘êÏ» Ï¿Ï«Ï┤Ï». Ï»Ï▒ Ï¡┘êÏ▓┘ç ϼ┘êϺ┘åÔÇîÏ│ϺÏ▓█îÏî ┌»Ï▓ϺÏ▒Ï┤ÔÇî┘çϺ█î ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ ┌ÿ┘êÏ▒┘åϺ┘äÔÇî┘çϺ█î Ï▓█îϿϺ█î█îÔÇôϬÏ▒┘à█î┘à█î ϡϺ┌®█î ϺÏ▓ Ïó┘å ϺÏ│Ϭ ┌®┘ç ϬÏ▒┌®█îÏ¿ Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ϿϺ ┘ä█îÏ▓Ï▒ ┘üÏ▒┌®Ï┤┘åϺ┘äÏî ┘à█î┌®Ï▒┘ê┘å█îÏ»┘ä█î┘å┌» ┘ê Ï│Ϻ█îÏ▒ ┘üÏ▒Ϻ█î┘åÏ»┘çϺ█î ┌®┘àÔÇî Ϭ┘çϺϼ┘à█îÏî Ï»Ï▒ Ï¿┘çÏ¿┘êÏ» ┌å█î┘å ÔÇî┘ê┌åÏ▒┘ê┌®Ïî ϺÏ│┌®ÏºÏ▒ Ïó┌®┘å┘ç ┘ê ÏóϬÏ▒┘ê┘ü█î ┘¥┘êÏ│Ϭ█î ┘åϬϺ█îϼ Ϻ┘à█îÏ»┘êϺÏ▒┌®┘å┘åÏ»┘çÔÇîϺ█î ϻϺÏ┤Ϭ┘ç ┘ê ┘àÏ│█îÏ▒ ÏÀÏ▒Ϻϡ█î ┘¥Ï▒┘êϬ┌®┘äÔÇî┘çϺ█î Ï┤Ï«ÏÁ█îÔÇîÏ│ϺÏ▓█îÔÇîÏ┤Ï»┘ç Ï»Ï▒ ┌®┘ä█î┘å█î┌®ÔÇî┘çϺ█î ┘¥┘êÏ│Ϭ ┘ê ┘à┘ê Ï▒Ϻ ┘ç┘à┘êϺÏ▒ ┌®Ï▒Ï»┘ç ϺÏ│Ϭ.

Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬á┘ê ┘àÏ»█îÏ▒█îϬ Ï»Ï▒Ï» ┘àÏ▓┘à┘å

Ï»Ï▒Ï» ┘àÏ▓┘à┘å ϺÏ│┌®┘äϬ█îÔÇî-Ï╣ÏÂ┘äϺ┘å█î ┘ê ┘à┘üÏÁ┘ä█î █î┌®█î ϺÏ▓ Ï┤Ϻ█îÏ╣ÔÇîϬÏ▒█î┘å Ï»┘äϺ█î┘ä ┘àÏ▒ϺϼÏ╣┘ç Ï¿█î┘àϺÏ▒Ϻ┘å Ï¿┘ç ┌®┘ä█î┘å█î┌®ÔÇî┘çϺ█î ÏÀÏ¿ ┘ü█îÏ▓█î┌®█î ϺÏ│Ϭ ┘ê Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬áÏ»Ï▒ ┌®┘åϺÏ▒ Ï│Ϻ█îÏ▒ Ï»Ï▒┘àϺ┘å┘çϺ█î Ϭ┘êϺ┘åÔÇîÏ¿Ï«Ï┤█îÏî Ï¿┘çÔÇîÏ╣┘å┘êϺ┘å Ï▒┘ê█î┌®Ï▒Ï»█î ┘å┘ê█î┘å Ï»Ï▒ ┘àÏ»█îÏ▒█îϬ Ϻ█î┘å Ï»Ï▒Ï»┘çϺ ┘àÏÀÏ▒Ï¡ Ï┤Ï»┘ç ϺÏ│Ϭ. Ï¿┘ç ┘å┘é┘ä ϺÏ▓ ┘àÏÀϺ┘äÏ╣ϺϬ ┘à┘åϬÏ┤Ï▒ Ï┤Ï»┘ç Ï»Ï▒ Stem Cell Research & Therapy ┘ê Regenerative TherapyÏî ϬÏ▓Ï▒█î┘é MSC┘çϺ ┘ê ┘àÏ¡ÏÁ┘ê┘äϺϬ ┘àÏ┤Ϭ┘é ϺÏ▓ ϿϺ┘üϬ ┌åÏ▒Ï¿█î Ï»Ï▒ ϺÏ│ϬϪ┘êÏóÏ▒ϬÏ▒█îϬ Ï▓Ϻ┘å┘ê Ï╣┘äϺ┘ê┘ç Ï¿Ï▒ ϺϽÏ▒ϺϬ Ï│ϺϫϬϺÏ▒█î Ï¿Ï▒ Ï║ÏÂÏ▒┘ê┘ü ┘ê Ï│█î┘å┘ê┘ê█î┘ê┘àÏî ϿϺÏ╣Ͻ ┌®Ïº┘çÏ┤ ┘àÏ╣┘åϺϻϺÏ▒ Ï┤ϻϬ Ï»Ï▒Ï»Ïî ┌®Ïº┘çÏ┤ ┘àÏÁÏ▒┘ü ϻϺÏ▒┘ê┘çϺ█î ÏÂϻϺ┘äϬ┘çϺϿ Ï║█îÏ▒ϺÏ│ϬÏ▒┘êϪ█îÏ»█î ┘ê Ï¿┘çÏ¿┘êÏ» ┌®█î┘ü█îϬ Ï▓┘åÏ»┌»█î Ï¿█î┘àϺÏ▒Ϻ┘å ┘à█îÔÇîÏ┤┘êÏ».

Ï»Ï▒ ┘à┘êÏ▒Ï» Ï»Ï▒Ï»┘çϺ█î ┘å┘êÏ▒┘ê┘¥ÏºÏ¬█î┌®Ïî Ï┤┘êϺ┘çÏ» ϿϺ┘ä█î┘å█î ┘ç┘å┘êÏ▓ ┘àÏ¡Ï»┘êÏ» ϺÏ│ϬÏî Ϻ┘àϺ ┘àÏÀϺ┘äÏ╣ϺϬ ┘¥█îÏ┤ÔÇîϿϺ┘ä█î┘å█î ┘åÏ┤Ϻ┘å ┘à█îÔÇîÏ»┘ç┘åÏ» ┌®┘ç MSC┘çϺ ┘à█îÔÇîϬ┘êϺ┘å┘åÏ» ϿϺ ϬÏ╣Ï»█î┘ä ┘üÏ╣Ϻ┘ä█îϬ ┘à█î┌®Ï▒┘ê┌»┘ä█îϺÏî ┌®Ïº┘çÏ┤ Ï│█îϬ┘ê┌®Ïº█î┘åÔÇî┘çϺ█î Ϻ┘äϬ┘çϺϿ█î ┘ê Ï¡┘àϺ█îϬ Trophic ϺÏ▓ ┘å┘êÏ▒┘ê┘åÔÇî┘çϺÏî ÏóÏ│ϬϺ┘å┘ç Ï»Ï▒Ï» Ï▒Ϻ Ϻ┘üÏ▓Ϻ█îÏ┤ ┘ê Ï┤ϻϬ Ï»Ï▒Ï» Ï▒Ϻ ┌®Ïº┘çÏ┤ Ï»┘ç┘åÏ». ϺϻÏ║Ϻ┘à Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ϿϺ ┘ü█îÏ▓█î┘êϬÏ▒Ϻ┘¥█îÏî Ϭ┘àÏ▒█î┘åÔÇîÏ»Ï▒┘àϺ┘å█îÏî ┘àϻϺϫ┘äϺϬ Ï»Ï▒Ï» ┘ê ϺÏÁ┘äϺϡ Ï╣┘êϺ┘à┘ä Ï«ÏÀÏ▒Ïî ┌å┘çϺÏ▒┌å┘êÏ¿█î ┌å┘åÏ»Ï▒Ï┤Ϭ┘çÔÇîϺ█î Ï¿Ï▒Ϻ█î ┘àÏ»█îÏ▒█îϬ Ï»Ï▒Ï» ┘àÏ▓┘à┘å Ϻ█îϼϺϻ ┘à█îÔÇî┌®┘åÏ» ┌®┘ç ┘à█îÔÇîϬ┘êϺ┘åÏ» Ï»Ï▒ ┘éϺ┘äÏ¿ ┘ç┘à┌®ÏºÏ▒█î ┘àÏ▒Ϻ┌®Ï▓ ϬϫÏÁÏÁ█î ϿϺ ┘ê█îÏ▒Ϻ Ï│┘ä┘ê┘äÏî Ï¿┘çÔÇîÏÁ┘êÏ▒Ϭ ┘¥Ï▒┘êϬ┌®┘äÔÇî┘çϺ█î Ï┤Ï«ÏÁ█îÔÇîÏ│ϺÏ▓█îÔÇîÏ┤Ï»┘ç Ï¿Ï▒Ϻ█î Ï¿█î┘àϺÏ▒Ϻ┘å ϺϼÏ▒Ϻ Ï┤┘êÏ».

Ï│┘ä┘ê┘ä ÔÇîÏ»Ï▒┘àϺ┘å█î ┬áÏ»Ï▒ Ï¿█î┘àϺÏ▒█îÔÇî┘çϺ█î Ï▓┘åϺ┘å ┘ê Ï▓Ϻ█î┘àϺ┘å

Ï│┘ä┘ê┘äÔÇî┘çϺ█î Ï¿┘å█îϺϻ█î ┘àÏ▓Ϻ┘åÏ┤█î┘à█î ÏÀ█î Ï│Ϻ┘äÔÇî┘çϺ█î Ϻϫ█îÏ▒ Ï¿┘çÔÇîÏ╣┘å┘êϺ┘å █î┌® Ï▒┘ê█î┌®Ï▒Ï» Ï»Ï▒┘àϺ┘å█î ┘å┘ê█îϻϿϫÏ┤ Ï»Ï▒ Ï¡┘êÏ▓┘ç Ï¿█î┘àϺÏ▒█îÔÇî┘çϺ█î Ï▓┘åϺ┘å ┘ê Ï▓Ϻ█î┘àϺ┘å ┘à┘êÏ▒Ï» Ϭ┘êϼ┘ç ┌»Ï│ϬÏ▒Ï»┘ç ┘éÏ▒ϺÏ▒ ┌»Ï▒┘üϬ┘çÔÇîϺ┘åÏ» ┘ê ϺϽÏ▒ϺϬ Ï»Ï▒┘àϺ┘å█î Ïó┘åÔÇî┘çϺ Ï╣┘àϻϬϺ┘ï ϺÏ▓ ÏÀÏ▒█î┘é ┘à┌®Ïº┘å█îÏ│┘àÔÇî┘çϺ█î ϬÏ▒┘à█î┘à█îÏî ┘¥ÏºÏ▒Ϻ┌®Ï▒█î┘å ┘ê Ϻ█î┘à┘ê┘å┘ê┘àÏ»┘ê┘äϺϬ┘êÏ▒█î ϺÏ╣┘àϺ┘ä ┘à█îÔÇîÏ┤┘êÏ». Ï┤┘êϺ┘çÏ» ϡϺÏÁ┘ä ϺÏ▓ ┘àÏÀϺ┘äÏ╣ϺϬ ϿϺ┘ä█î┘å█î ┘åÏ┤Ϻ┘å ┘à█îÔÇîÏ»┘çÏ» ┌®┘ç Ï│┘ä┘ê┘äÔÇîÏ»Ï▒┘àϺ┘å█î ┘àϿϬ┘å█î Ï¿Ï▒ MSC ┘à█îÔÇîϬ┘êϺ┘åÏ» Ï»Ï▒ Ï¿█î┘àϺÏ▒Ϻ┘å ┘àϿϬ┘äϺ Ï¿┘ç ┘åϺÏ▒Ï│Ϻ█î█î Ï▓┘êÏ»Ï▒Ï│ Ϭϫ┘àϻϺ┘å (Premature Ovarian Insufficiency) ┬áϿϺ Ï¿┘çÏ¿┘êÏ» ┘¥Ï▒┘ê┘üϺ█î┘ä ┘ç┘êÏ▒┘à┘ê┘å█îÏî Ϻ┘üÏ▓Ϻ█îÏ┤ ϬÏ╣ϻϺϻ ┘ü┘ê┘ä█î┌®┘ê┘äÔÇî┘çϺ█î Ϭϫ┘àϻϺ┘å█î ┘ê ϺÏ▒Ϭ┘éϺ█î Ï╣┘à┘ä┌®Ï▒Ï» Ϭϫ┘àϻϺ┘åÏî ┘à┘åϼÏ▒ Ï¿┘ç ϿϺÏ▓█îϺϿ█î ┌åÏ▒Ï«┘ç ┘éϺÏ╣Ï»┌»█î ┘ê Ï¿┘çÏ¿┘êÏ» ┘¥Ï¬Ïº┘åÏ│█î┘ä ϿϺÏ▒┘êÏ▒█î Ï┤┘êÏ».

Ï»Ï▒ Ï│ÏÀÏ¡ Ï▒Ï¡┘à ┘ê Ïó┘åÏ»┘ê┘àϬÏ▒Ïî MSC┘çϺ ϿϺ Ϻ┘üÏ▓Ϻ█îÏ┤ ÏÂϫϺ┘àϬ Ïó┘åÏ»┘ê┘àϬÏ▒Ïî ┌®Ïº┘çÏ┤ ┘ü█îÏ¿Ï▒┘êÏ▓ ϿϺ┘üϬ█î ┘ê Ï¿┘çÏ¿┘êÏ» Ï▒┌»ÔÇîÏ▓Ϻ█î█î (Neoangiogenesis)Ïî ┘å┘éÏ┤ ┘àÏñϽÏ▒█î Ï»Ï▒ ϿϺÏ▓Ï│ϺÏ▓█î Ï│ϺϫϬϺÏ▒ ┘ê Ï╣┘à┘ä┌®Ï▒Ï» Ϻ┘åÏ»┘ê┘àϬÏ▒ Ϻ█î┘üϺ ┘à█îÔÇî┌®┘å┘åÏ». Ï¿Ï▒ Ϻ█î┘å ϺÏ│ϺÏ│Ïî Ï»Ï▒ Ï¿█î┘àϺÏ▒Ϻ┘å ┘àϿϬ┘äϺ Ï¿┘ç Ï│┘åÏ»Ï▒┘à ÏóÏ┤Ï▒┘à┘å ┘ê Ïó┘åÏ»┘ê┘àϬÏ▒ ┘åϺÏ▓┌® ┘ç┘àÏ▒Ϻ┘ç ϿϺ ┘åϺϿϺÏ▒┘êÏ▒█îÏî ϺÏ│Ϭ┘üϺϻ┘ç ϺÏ▓ MSC ϿϺ Ï¿┘çÏ¿┘êÏ» ┘üÏ▒Ïó█î┘åÏ» ┘äϺ┘å┘çÔÇî┌»Ï▓█î┘å█î ϼ┘å█î┘å ┘ê Ϻ┘üÏ▓Ϻ█îÏ┤ ┘åÏ▒Ï« ϿϺÏ▒ϻϺÏ▒█î ┘ç┘àÏ▒Ϻ┘ç Ï¿┘êÏ»┘ç ϺÏ│Ϭ.

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