What is Stromal
Vascular Fraction (SVF)?
Stromal Vascular Fraction (SVF) is a mixture of cells, growth factors, and other bioactive molecules that are obtained from adipose tissue through a process called lipoaspiration.
SVF contains a variety of cell types, including mesenchymal stem cells, endothelial cells, pericytes, and immune cells. SVF has been explored as a regenerative therapy to potentially promote tissue repair and alleviate symptoms in conditions such as osteoarthritis, tendon injuries, ligament injuries, and bone fractures. Furthermore, SVF has been investigated for its potential effects in various rheumatic diseases, which encompass a range of autoimmune and inflammatory conditions affecting the joints, connective tissues, and other systems.
Applications:
- Lumbar disc
- Osteoarthritis
- Tendon damage or rupture
- Ligament injury
- Cartilage damage
- Sport injuries such as strains
- Repair tissues after orthopedic surgeries
- Rheumatoid and ankylosing arthritis
SVFoenix Mechanisms of Action
1. Anti-inflammatory Properties:
SVF contains various types of immune cells, such as mesenchymal stem cells, regulatory T cells and M2 macrophages, that have anti-inflammatory properties in injured tissues. SVF cells also secrete a range of cytokines and growth factors such as nterleukin-10 (IL-10) and transforming growth factor beta (TGF- ). that influence immune cell behavior. SVF could provide relief from pain, which is a hallmark of many rheumatic diseases. Conditions like fibromyalgia, characterized by widespread pain, might particularly benefit from SVF1 s pain-modulating effects.
2. Stem Cell Potential:
SVF contains a population of mesenchymal stem cells (MSCs). These stem eel Is possess the remarkable ability to differentiate into various cell types, including those found in bone, cartilage, and other connective tissues. For instance, in cases of bone fractures, MSCs could differentiate into osteoblasts. aiding in the repair of the fractured bone. In rheumatic diseases, where joint and connective tissue damage is common, SVF might can be helpful in the restoration of damaged tissues
3. Paracrine Effects:
SVF1 s paracrine effects involve the secretion of a range of signaling molecules, growth factors, and cytokines into the local microenvironment. These secreted factors can influence nearby cells and tissues, orchestrating various cellular responses that collectively promote healing, tissue regeneration and anti-inflammatory effects.
4. Angiogenic Effects:
Angiogenesis, the formation of new blood vessels, is a critical process in tissue repair and regeneration. SVF contributes to angiogenesis through multiple mechanisms. The cells within SVF, such as endothelial cells and pericytes, have the potential to promote blood vessel growth. Furthermore, the growth factors and cytokines secreted by SVF cells, including VEGF and FGF, act as potent angiogenic factors.
5. Extracellular Matrix Modulation:
In Bone and joints, the integrity and composition of the extracellular matrix (ECM) are crucial for proper healing and tissue function. SVF-derived cells, particularly MSCs, can secrete factors that stimulate the production of ECM components like collagen and proteoglycans, which are essential for the formation of functional connective tissues like tendons and cartilage. Additionally, SVF1s paracrine effects can promote the remodeling of the ECM by regulating the balance between ECM- degrading enzymes and ECMproducing cells.
A Remarkable 3-5-Fold Increase in Platelet Counts
Applications:
- Osteoarthritis
- Tendon damage or rupture
- Ligament injury
- Cartilage damage
- Sport injuries such as strains
- Repair tissues after orthopedic surgeries
- Rheumatoid arthritis
A Superior PRP Kit PRPrime Specifications:
- Highest PRP yield
- Best platelet purity
- Red blood cells free
- Gel/ acrylate/ chemical free
- Biomedica I grade materia Is
- Certified protocol
PRPrime contains high levels of platelets and when injected into bone 6 joint, growth factors are released, which are vital for tissue healing and repair. PRPrime could be used in conjunction with treatments such as hyaluronic acid, to directly address and amplify the health of tissue.
PRPrime Consist of
Platelets usually begin secreting their growth factors immediately, a process known as degranulation, releasing almost 100% of their growth factors within an hour. Platelets may continue to release some growth factors throughout the rest of their lifespan, typically 7-10 days.
The Highest platelets and growth factors in less volume and time
PRFort Specifications:
- Higher regenerative cells
- More and longer release of growth factors
- Red blood cells free
- No Foreign Components
- Biomedical grade materials
- Certified protocol
Applications:
- Osteoarthritis
- Tendon damage or rupture
- Ligament injury
- Cartilage damage
- Sport injuries such as strains
- Repair tissues after orthopedic surgeries
- Rheumatoid arthritis
Platelet rich fibrin (PRF) is second-generation PRP in which platelets, leukocytes, stem cells, and growth factors are trapped in the fibrin matrix. This is particularly important where higher concentration and longer release of cells and growth factors in PRF compared to PRP sample.
PRFort Consist of
